Alteplase - Revision history

Rossdonaldson1: /* Adult Dosing */

2026-04-08T19:55:56Z

Adult Dosing

← Older revision		Revision as of 19:55, 8 April 2026
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	===[[Thrombolytics for pulmonary embolism\|Massive PE]]===		===[[Thrombolytics for pulmonary embolism\|Massive PE]]===
	*Stable Massive PE: 100mg IV over 2 hr '''OR''' 0.6mg/kg over 2 min		*Stable Massive PE: 100mg IV over 2 hr '''OR''' 0.6mg/kg over 2 min
	*Cardiac arrest: 50mg IV over 2 min followed by 50mg IV after 15 min if needed		*Cardiac arrest: 50mg IV over 2 min (0.6 mg/kg if <70 kg), followed by 50mg IV after 15 min if needed

	===Arterial thrombosis===		===Arterial thrombosis===

2026-03-20T21:58:03Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T20:36:37Z

Add MedicationDose SMW query table for dynamic indications by condition

← Older revision		Revision as of 20:36, 20 March 2026
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	==Comments==		==Comments==

			==Indications by Condition==
			''The following table is automatically generated from disease/condition pages across WikEM.''

			{{#ask:[[Has DrugName::Alteplase]]
			\|?Has Indication=Indication
			\|?Has Dose=Dose
			\|?Has Context=Context
			\|?Has Route=Route
			\|?Has Population=Population
			\|format=broadtable
			\|headers=plain
			\|mainlabel=-
			\|sort=Has Indication
			\|limit=50
			}}

	==See Also==		==See Also==

2020-05-06T11:38:11Z

Serious

← Older revision		Revision as of 11:38, 6 May 2020
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	*Pulmonary edema, pleural effusion		*Pulmonary edema, pleural effusion
	*Cardiac dysrhythmia		*Cardiac dysrhythmia
	**Anaphylaxis or angioedema		*Anaphylaxis or angioedema
	**Stop tPA immediately		**Stop tPA immediately
	**Epinephrine 0.3 mg IM		**Epinephrine 0.3 mg IM

2020-05-06T11:37:51Z

Serious

← Older revision		Revision as of 11:37, 6 May 2020
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*~~Bleeding!~~ [[Post-tPA Hemorrhage in CVA]]		*Intracranial hemorrhage - see [[Post-tPA Hemorrhage in CVA]]
	*GI bleed		*GI bleed
	*Pericardial effusion, pericarditis, cardiac tamponade		*Pericardial effusion, pericarditis, cardiac tamponade
	*Intracranial hemorrhage, cerebral herniation
	*Stroke, seizure		*Stroke, seizure
	*Anaphylaxis, angioedema
	*Pulmonary edema, pleural effusion		*Pulmonary edema, pleural effusion
	*Cardiac dysrhythmia		*Cardiac dysrhythmia
	*~~Post-tPA Airway Edema~~		**Anaphylaxis or angioedema
	**Stop tPA immediately		**Stop tPA immediately
			**Epinephrine 0.3 mg IM
	**Famotidine 40 mg IV		**Famotidine 40 mg IV
	**Diphenhydramine 50 mg IV		**Diphenhydramine 50 mg IV

2019-11-27T20:48:07Z

Serious

← Older revision		Revision as of 20:48, 27 November 2019
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*Bleeding!		*Bleeding! [[Post-tPA Hemorrhage in CVA]]
	*GI bleed		*GI bleed
	*Pericardial effusion, pericarditis, cardiac tamponade		*Pericardial effusion, pericarditis, cardiac tamponade
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	*Pulmonary edema, pleural effusion		*Pulmonary edema, pleural effusion
	*Cardiac dysrhythmia		*Cardiac dysrhythmia
			*Post-tPA Airway Edema
			**Stop tPA immediately
			**Famotidine 40 mg IV
			**Diphenhydramine 50 mg IV
			**Methylprednisolone 125 mg IV
			**Consider early airway management PRN

	===Common===		===Common===

2019-09-19T16:45:49Z

← Older revision		Revision as of 16:45, 19 September 2019
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	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]] [[Category:Cardiology]] [[Category:Vascular]] [[Category:Neurology]]

2019-07-25T15:10:29Z

Massive PE

← Older revision		Revision as of 15:10, 25 July 2019
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	===[[Thrombolytics for pulmonary embolism\|Massive PE]]===		===[[Thrombolytics for pulmonary embolism\|Massive PE]]===
	*100mg IV over ~~2hr~~ '''OR''' 0.6mg/kg over ~~2min~~		*Stable Massive PE: 100mg IV over 2 hr '''OR''' 0.6mg/kg over 2 min
			*Cardiac arrest: 50mg IV over 2 min followed by 50mg IV after 15 min if needed

	===Arterial thrombosis===		===Arterial thrombosis===

2019-03-05T06:17:20Z

Acute ischemic stroke

← Older revision		Revision as of 06:17, 5 March 2019
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	===[[Thrombolytics for acute ischemic stroke\|Acute ischemic stroke]]===		===[[Thrombolytics for acute ischemic stroke\|Acute ischemic stroke]]===
	*0.9mg/kg IV (max 90mg total)		*0.9mg/kg IV (max 90mg total)
	**10% of dose is administered as bolus; rest is given over ~~60min~~		**10% of dose is administered as bolus; rest is given over 60 minutes

	===[[Thrombolytics for pulmonary embolism\|Massive PE]]===		===[[Thrombolytics for pulmonary embolism\|Massive PE]]===

2019-03-05T06:17:10Z

Acute ischemic stroke

← Older revision		Revision as of 06:17, 5 March 2019
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	*≤67kg: 15mg IV over 1-2min; then 0.75 mg/kg (max 50mg) IV over 30 min; then 0.5 mg/kg over 60min (max 35 mg)		*≤67kg: 15mg IV over 1-2min; then 0.75 mg/kg (max 50mg) IV over 30 min; then 0.5 mg/kg over 60min (max 35 mg)

	===~~Acute~~ [[ischemic stroke]]===		===[[Thrombolytics for acute ischemic stroke\|Acute ischemic stroke]]===
	*0.9mg/kg IV (max 90mg total)		*0.9mg/kg IV (max 90mg total)
	**10% of dose is administered as bolus; rest is given over 60min		**10% of dose is administered as bolus; rest is given over 60min