Lactulose - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:27Z

Switch SMW query from broadtable to table format for better layout with TOC

← Older revision		Revision as of 21:57, 20 March 2026
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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Add SMW Indications by Condition query table

2026-03-20T18:39:49Z

Add SMW Indications by Condition query table

← Older revision		Revision as of 18:39, 20 March 2026
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	==Comments==		==Comments==


			==Indications by Condition==
			''The following table is automatically generated from disease/condition pages across WikEM.''

			{{#ask:[[Has DrugName::Lactulose]]
			\|?Has Indication=Indication
			\|?Has Dose=Dose
			\|?Has Context=Context
			\|?Has Route=Route
			\|?Has Population=Population
			\|format=broadtable
			\|headers=plain
			\|mainlabel=-
			\|sort=Has Indication
			\|limit=50
			}}

Ostermayer: Prepared the page for translation

2026-01-04T23:15:37Z

Prepared the page for translation

← Older revision		Revision as of 23:15, 4 January 2026
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			<languages/>
			<translate>

	==General==		==General==
	*Type: osmotic [[laxative]]
			*Type: osmotic [[Special:MyLanguage/laxative\|laxative]]
	*Dosage Forms: 10g/15mL solution		*Dosage Forms: 10g/15mL solution
	*Routes of Administration: oral, NG, rectal		*Routes of Administration: oral, NG, rectal
	*Common Trade Names: Kristalose		*Common Trade Names: Kristalose


	==Adult Dosing==		==Adult Dosing==
	===[[Hepatic encephalopathy]]===

			===[[Special:MyLanguage/Hepatic encephalopathy\|Hepatic encephalopathy]]===

	*30-45mg PO TID or QID or (300mL in 700cc H2O retention enema x30min)		*30-45mg PO TID or QID or (300mL in 700cc H2O retention enema x30min)
	*titrate for 2-3 soft stools per day		*titrate for 2-3 soft stools per day

	===[[Constipation]]===
			===[[Special:MyLanguage/Constipation\|Constipation]]===

	*15-50mL PO Qday - BID		*15-50mL PO Qday - BID
	*max 60mL/day		*max 60mL/day


	==Pediatric Dosing==		==Pediatric Dosing==


	===Portal systemic encephalopathy===		===Portal systemic encephalopathy===

	*infants		*infants
	**2.5-10ml/day PO divided TID-QID		**2.5-10ml/day PO divided TID-QID
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	**titrate for 2-3 soft stools per day		**titrate for 2-3 soft stools per day

	===[[Constipation (peds)\|Constipation]]===
			===[[Special:MyLanguage/Constipation (peds)\|Constipation]]===

	*1ml/kg PO Qday - BID		*1ml/kg PO Qday - BID
	*max 60mL/day		*max 60mL/day


	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: B (no evidence of risk)
	*[[Lactation risk categories\|Lactation risk]]: safety unknown		*[[Special:MyLanguage/Drug Ratings in Pregnancy\|Pregnancy Rating]]: B (no evidence of risk)
			*[[Special:MyLanguage/Lactation risk categories\|Lactation risk]]: safety unknown
	*Renal Dosing		*Renal Dosing
	**Adult: not defined		**Adult: not defined
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	**Adult: not defined		**Adult: not defined
	**Pediatric: not defined		**Pediatric: not defined


	==Contraindications==		==Contraindications==

	*Allergy to class/drug		*Allergy to class/drug
	*galactosemia		*galactosemia
	*caution in DM		*caution in DM
	*caution if colorectal electrocautery procedures		*caution if colorectal electrocautery procedures


	==Adverse Reactions==		==Adverse Reactions==


	===Serious===		===Serious===

	*diarrhea, severe (excessive dose)		*diarrhea, severe (excessive dose)
	*electrolyte disorders (excessive dose)		*electrolyte disorders (excessive dose)
	*metabolic acidosis (excessive dose)		*metabolic acidosis (excessive dose)


	===Common===		===Common===

	*flatulence		*flatulence
	*intestinal cramping		*intestinal cramping
	*abdominal distention		*abdominal distention
	*nausea/vomiting		*nausea/vomiting


	==Pharmacology==		==Pharmacology==

	*Half-life: unknown		*Half-life: unknown
	*Metabolism: colon, <3% systemic absorption		*Metabolism: colon, <3% systemic absorption
	*Excretion: feces (100% unchanged), urine < 3%		*Excretion: feces (100% unchanged), urine < 3%


	==Mechanism of Action==		==Mechanism of Action==

	*Undigestible disaccharide consumed by large bowel bacteria and broken down to lactic acid		*Undigestible disaccharide consumed by large bowel bacteria and broken down to lactic acid
	*Acidification of colonic contents attracts ammonia from bloodstream leading to excretion in stool		*Acidification of colonic contents attracts ammonia from bloodstream leading to excretion in stool


	==Comments==		==Comments==


	==See Also==		==See Also==
	*[[Hepatic encephalopathy]]
	*[[Constipation]]		*[[Special:MyLanguage/Hepatic encephalopathy\|Hepatic encephalopathy]]
			*[[Special:MyLanguage/Constipation\|Constipation]]


	==References==		==References==

	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	[[Category:GI]]		[[Category:GI]]
			</translate>

Elcatracho: /* Pharmacology */

2021-02-10T19:55:34Z

Pharmacology

← Older revision		Revision as of 19:55, 10 February 2021
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	*Metabolism: colon, <3% systemic absorption		*Metabolism: colon, <3% systemic absorption
	*Excretion: feces (100% unchanged), urine < 3%		*Excretion: feces (100% unchanged), urine < 3%
	*Mechanism of Action~~: increases stool water content, increases~~ stool ~~acidity trapping NH4 ions~~
			==Mechanism of Action==
			*Undigestible disaccharide consumed by large bowel bacteria and broken down to lactic acid
			*Acidification of colonic contents attracts ammonia from bloodstream leading to excretion in stool

	==Comments==		==Comments==

Jmh649: /* General */ fixed

2020-08-05T17:02:31Z

General: fixed

← Older revision		Revision as of 17:02, 5 August 2020
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	==General==		==General==
	*Type: osmotic [[laxative]]		*Type: osmotic [[laxative]]
	*Dosage Forms: 10g/~~15L~~ solution		*Dosage Forms: 10g/15mL solution
	*Routes of Administration: oral, NG, rectal		*Routes of Administration: oral, NG, rectal
	*Common Trade Names: Kristalose		*Common Trade Names: Kristalose

ClaireLewis: /* References */

2019-09-22T22:50:09Z

References

← Older revision		Revision as of 22:50, 22 September 2019
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	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:GI]]

Rossdonaldson1: /* General */

2016-08-01T04:04:51Z

General

← Older revision		Revision as of 04:04, 1 August 2016
Line 1:		Line 1:
	==General==		==General==
	*Type: osmotic laxative		*Type: osmotic [[laxative]]
	*Dosage Forms: 10g/15L solution		*Dosage Forms: 10g/15L solution
	*Routes of Administration: oral, NG, rectal		*Routes of Administration: oral, NG, rectal

ClaireLewis: /* See Also */

2016-07-14T22:14:17Z

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:52:39Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 15:52, 22 March 2016
Line 69:		Line 69:
	==References==		==References==
	<references/>		<references/>
	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]

Rossdonaldson1: /* See Also */

2015-09-03T12:35:14Z

← Older revision		Revision as of 22:14, 14 July 2016
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	==See Also==		==See Also==
	*[[Hepatic encephalopathy]]		*[[Hepatic encephalopathy]]
			*[[Constipation]]

	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

← Older revision		Revision as of 12:35, 3 September 2015
Line 65:		Line 65:

	==See Also==		==See Also==
	[[~~hepatic~~ encephalopathy]]		*[[Hepatic encephalopathy]]

	==References==		==References==
	<references/>		<references/>
	[[Category:Drugs]]		[[Category:Drugs]]