Nonbenzodiazepine - Revision history

Rossdonaldson1: /* Background */

2026-05-20T23:26:40Z

Background

← Older revision		Revision as of 23:26, 20 May 2026
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	*Nonbenzodiazepine pharmacodynamics are similar in mechanism of action to benzodiazepine drugs, acting as GABAA receptor positive allosteric modulators of the benzodiazepine site, and therefore exhibit similar benefits, side effects, and risks.		*Nonbenzodiazepine pharmacodynamics are similar in mechanism of action to benzodiazepine drugs, acting as GABAA receptor positive allosteric modulators of the benzodiazepine site, and therefore exhibit similar benefits, side effects, and risks.
	**However, nonbenzodiazepines have dissimilar or entirely different chemical structures, so are unrelated to benzodiazepines on a molecular level.		**However, nonbenzodiazepines have dissimilar or entirely different chemical structures, so are unrelated to benzodiazepines on a molecular level.
			*'''[[High-risk geriatric medication]]!'''

	==Classes==		==Classes==

Rossdonaldson1: /* Classes */

2026-05-20T21:52:44Z

Classes

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	==Classes==		==Classes==
	'''Imidazopyridines'''		'''Imidazopyridines'''
	* Alpidem
	* Necopidem
	* Saripidem
	* [[Zolpidem]] (Ambien, Ambien CR, Intermezzo, Zolpimist, Edluar, Ivadal, Sanval, Stilnox, etc.)		* [[Zolpidem]] (Ambien, Ambien CR, Intermezzo, Zolpimist, Edluar, Ivadal, Sanval, Stilnox, etc.)
	'''Pyrazolopyrimidines'''		'''Pyrazolopyrimidines'''
	* Divaplon
	* Fasiplon
	* Indiplon
	* Lorediplon
	* Ocinaplon
	* Panadiplon
	* Taniplon
	* [[Zaleplon]] (Sonata, Starnoc, Andante)		* [[Zaleplon]] (Sonata, Starnoc, Andante)
	'''Cyclopyrrolones'''		'''Cyclopyrrolones'''
	* [[Eszopiclone]] (Lunesta, Valnoc, etc.)		* [[Eszopiclone]] (Lunesta, Valnoc, etc.)
	* Pagoclone
	* Pazinaclone
	* Suproclone
	* Suriclone
	* [[Zopiclone]] (Imovane, Zimovane, Somnol, etc.)		* [[Zopiclone]] (Imovane, Zimovane, Somnol, etc.)
	'''β-Carbolines'''		'''β-Carbolines'''
	* ~~Abecarnil~~		* None clinically available
	* Azocarnil
	* Gedocarnil

	==See Also==		==See Also==

Rossdonaldson1: /* Classes */

2026-05-20T21:51:04Z

Classes

← Older revision		Revision as of 21:51, 20 May 2026
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	==Classes==		==Classes==
	'''Imidazopyridines'''		'''Imidazopyridines'''
	* [[Alpidem]]		* Alpidem
	* [[Necopidem]]		* Necopidem
	* [[Saripidem]]		* Saripidem
	* [[Zolpidem]] (Ambien, Ambien CR, Intermezzo, Zolpimist, Edluar, Ivadal, Sanval, Stilnox, etc.)		* [[Zolpidem]] (Ambien, Ambien CR, Intermezzo, Zolpimist, Edluar, Ivadal, Sanval, Stilnox, etc.)
	'''Pyrazolopyrimidines'''		'''Pyrazolopyrimidines'''
	* [[Divaplon]]		* Divaplon
	* [[Fasiplon]]		* Fasiplon
	* [[Indiplon]]		* Indiplon
	* [[Lorediplon]]		* Lorediplon
	* [[Ocinaplon]]		* Ocinaplon
	* [[Panadiplon]]		* Panadiplon
	* [[Taniplon]]		* Taniplon
	* [[Zaleplon]] (Sonata, Starnoc, Andante)		* [[Zaleplon]] (Sonata, Starnoc, Andante)
	'''Cyclopyrrolones'''		'''Cyclopyrrolones'''
	* [[Eszopiclone]] (Lunesta, Valnoc, etc.)		* [[Eszopiclone]] (Lunesta, Valnoc, etc.)
	* [[Pagoclone]]		* Pagoclone
	* [[Pazinaclone]]		* Pazinaclone
	* [[Suproclone]]		* Suproclone
	* [[Suriclone]]		* Suriclone
	* [[Zopiclone]] (Imovane, Zimovane, Somnol, etc.)		* [[Zopiclone]] (Imovane, Zimovane, Somnol, etc.)
	'''β-Carbolines'''		'''β-Carbolines'''
	* [[Abecarnil]]		* Abecarnil
	* [[Azocarnil]]		* Azocarnil
	* [[Gedocarnil]]		* Gedocarnil

	==See Also==		==See Also==

Rossdonaldson1 at 21:49, 20 May 2026

2026-05-20T21:49:57Z

← Older revision		Revision as of 21:49, 20 May 2026
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	* [[Azocarnil]]		* [[Azocarnil]]
	* [[Gedocarnil]]		* [[Gedocarnil]]

			==See Also==
			*[[Sedative/Hypnotic]]
			*[[Benzodiazepine]]

	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Rossdonaldson1: /* Classes */

2026-05-20T21:48:58Z

Classes

← Older revision		Revision as of 21:48, 20 May 2026
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	'''β-Carbolines'''		'''β-Carbolines'''
	* [[Abecarnil]]		* [[Abecarnil]]
	* [[Azocarnil ~~(photoswitchable)~~]]<ref>{{cite journal \| vauthors = Maleeva G, Nin-Hill A, Wirth U, Rustler K, Ranucci M, Opar E, Rovira C, Bregestovski P, Zeilhofer HU, König B, Alfonso-Prieto M, Gorostiza P \| title = Light-Activated Agonist-Potentiator of GABA<sub>A</sub> Receptors for Reversible Neuroinhibition in Wildtype Mice \| journal = Journal of the American Chemical Society \| date = October 2024 \| volume = 146 \| issue = 42 \| pages = 28822–28831 \| pmid = 39383450 \| doi = 10.1021/jacs.4c08446 \| pmc = 11503767 \| bibcode = 2024JAChS.14628822M }}</ref>		* [[Azocarnil]]
	* [[Gedocarnil]]		* [[Gedocarnil]]
	* [[SL-651,498]]
	* [[ZK-93423]]

	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Rossdonaldson1: /* Classes */

2026-05-20T21:48:29Z

Classes

← Older revision		Revision as of 21:48, 20 May 2026
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	==Classes==		==Classes==
	'''~~[[Imidazopyridine]]s~~'''		'''Imidazopyridines'''
	* [[Alpidem]]		* [[Alpidem]]
	* [[Necopidem]]		* [[Necopidem]]
	* [[Saripidem]]		* [[Saripidem]]
	* [[Zolpidem]] (Ambien, Ambien CR, Intermezzo, Zolpimist, Edluar, Ivadal, Sanval, Stilnox, etc.)		* [[Zolpidem]] (Ambien, Ambien CR, Intermezzo, Zolpimist, Edluar, Ivadal, Sanval, Stilnox, etc.)
	'''~~[[Pyrazolopyrimidine]]s~~'''		'''Pyrazolopyrimidines'''
	* [[Divaplon]]		* [[Divaplon]]
	* [[Fasiplon]]		* [[Fasiplon]]
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	* [[Taniplon]]		* [[Taniplon]]
	* [[Zaleplon]] (Sonata, Starnoc, Andante)		* [[Zaleplon]] (Sonata, Starnoc, Andante)
	'''~~[[Cyclopyrrolone]]s~~'''		'''Cyclopyrrolones'''
	* [[Eszopiclone]] (Lunesta, Valnoc, etc.)		* [[Eszopiclone]] (Lunesta, Valnoc, etc.)
	* [[Pagoclone]]		* [[Pagoclone]]
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	* [[Suriclone]]		* [[Suriclone]]
	* [[Zopiclone]] (Imovane, Zimovane, Somnol, etc.)		* [[Zopiclone]] (Imovane, Zimovane, Somnol, etc.)
	'''[[β-~~Carboline]]s~~'''		'''β-Carbolines'''
	* [[Abecarnil]]		* [[Abecarnil]]
	* [[Azocarnil (photoswitchable)]]<ref>{{cite journal \| vauthors = Maleeva G, Nin-Hill A, Wirth U, Rustler K, Ranucci M, Opar E, Rovira C, Bregestovski P, Zeilhofer HU, König B, Alfonso-Prieto M, Gorostiza P \| title = Light-Activated Agonist-Potentiator of GABA<sub>A</sub> Receptors for Reversible Neuroinhibition in Wildtype Mice \| journal = Journal of the American Chemical Society \| date = October 2024 \| volume = 146 \| issue = 42 \| pages = 28822–28831 \| pmid = 39383450 \| doi = 10.1021/jacs.4c08446 \| pmc = 11503767 \| bibcode = 2024JAChS.14628822M }}</ref>		* [[Azocarnil (photoswitchable)]]<ref>{{cite journal \| vauthors = Maleeva G, Nin-Hill A, Wirth U, Rustler K, Ranucci M, Opar E, Rovira C, Bregestovski P, Zeilhofer HU, König B, Alfonso-Prieto M, Gorostiza P \| title = Light-Activated Agonist-Potentiator of GABA<sub>A</sub> Receptors for Reversible Neuroinhibition in Wildtype Mice \| journal = Journal of the American Chemical Society \| date = October 2024 \| volume = 146 \| issue = 42 \| pages = 28822–28831 \| pmid = 39383450 \| doi = 10.1021/jacs.4c08446 \| pmc = 11503767 \| bibcode = 2024JAChS.14628822M }}</ref>

Rossdonaldson1: /* Classes */

2026-05-20T21:48:03Z

Classes

← Older revision		Revision as of 21:48, 20 May 2026
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	==Classes==		==Classes==
	~~Currently, the major chemical classes of nonbenzodiazepines are:~~

	'''[[Imidazopyridine]]s'''		'''[[Imidazopyridine]]s'''
	* [[Alpidem]]		* [[Alpidem]]

Rossdonaldson1: /* Background */

2026-05-20T21:47:50Z

Background

← Older revision		Revision as of 21:47, 20 May 2026
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	==Background==		==Background==
			[[File:Core structures of nonbenzodiazepines.svg\|thumb\|Core structures of selected nonbenzodiazepines (left three diagrams) and the structure of benzodiazepines (right) for comparison.]]
	*Nonbenzodiazepines (i.e., "Z-drugs"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia and anxiety.		*Nonbenzodiazepines (i.e., "Z-drugs"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia and anxiety.
	*Nonbenzodiazepine pharmacodynamics are similar in mechanism of action to benzodiazepine drugs, acting as GABAA receptor positive allosteric modulators of the benzodiazepine site, and therefore exhibit similar benefits, side effects, and risks.		*Nonbenzodiazepine pharmacodynamics are similar in mechanism of action to benzodiazepine drugs, acting as GABAA receptor positive allosteric modulators of the benzodiazepine site, and therefore exhibit similar benefits, side effects, and risks.

Rossdonaldson1 at 21:46, 20 May 2026

2026-05-20T21:46:28Z

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 *Nonbenzodiazepine pharmacodynamics are similar in mechanism of action to benzodiazepine drugs, acting as GABAA receptor positive allosteric modulators of the benzodiazepine site, and therefore exhibit similar benefits, side effects, and risks.
 **However, nonbenzodiazepines have dissimilar or entirely different chemical structures, so are unrelated to benzodiazepines on a molecular level.
 [[Category:Pharmacology]]

Rossdonaldson1 at 21:44, 20 May 2026

2026-05-20T21:44:56Z

← Older revision		Revision as of 21:44, 20 May 2026
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	*Nonbenzodiazepine pharmacodynamics are similar in mechanism of action to benzodiazepine drugs, acting as GABAA receptor positive allosteric modulators of the benzodiazepine site, and therefore exhibit similar benefits, side effects, and risks.		*Nonbenzodiazepine pharmacodynamics are similar in mechanism of action to benzodiazepine drugs, acting as GABAA receptor positive allosteric modulators of the benzodiazepine site, and therefore exhibit similar benefits, side effects, and risks.
	**However, nonbenzodiazepines have dissimilar or entirely different chemical structures, so are unrelated to benzodiazepines on a molecular level.		**However, nonbenzodiazepines have dissimilar or entirely different chemical structures, so are unrelated to benzodiazepines on a molecular level.

			[[Category:Pharmacology]]