Nonbenzodiazepine
Revision as of 21:46, 20 May 2026 by Rossdonaldson1 (talk | contribs)
Background
- Nonbenzodiazepines (i.e., "Z-drugs"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia and anxiety.
- Nonbenzodiazepine pharmacodynamics are similar in mechanism of action to benzodiazepine drugs, acting as GABAA receptor positive allosteric modulators of the benzodiazepine site, and therefore exhibit similar benefits, side effects, and risks.
- However, nonbenzodiazepines have dissimilar or entirely different chemical structures, so are unrelated to benzodiazepines on a molecular level.
Classes
Currently, the major chemical classes of nonbenzodiazepines are:
- Alpidem
- Necopidem
- Saripidem
- Zolpidem (Ambien, Ambien CR, Intermezzo, Zolpimist, Edluar, Ivadal, Sanval, Stilnox, etc.)
- Divaplon
- Fasiplon
- Indiplon
- Lorediplon
- Ocinaplon
- Panadiplon
- Taniplon
- Zaleplon (Sonata, Starnoc, Andante)
- Eszopiclone (Lunesta, Valnoc, etc.)
- Pagoclone
- Pazinaclone
- Suproclone
- Suriclone
- Zopiclone (Imovane, Zimovane, Somnol, etc.)
- ↑ Light-Activated Agonist-Potentiator of GABAA Receptors for Reversible Neuroinhibition in Wildtype Mice. Journal of the American Chemical Society
- 146(42)
- 28822–28831. doi:10.1021/jacs.4c08446. PMID 39383450. PMC 11503767.